Abstract：A substantial volume of coal gangue in China is generated in the Permian coalfield, however, research concerning the release pattern of nitrogen and organic matter from Permian gangue in different regions has been notably scarce. This study focuses on Baode coal mine and JiuLiShan mine, conducts constant temperature shock immersion experiment, which aim to compare and study the release law of nitrogen and organic matter in Permian coal gangue in the middle and western regions. Results showed that the nitrogen dissolved from the two mines was mainly ammonia nitrogen, and the dissolution had intermittent characteristics, in which the dissolution of "three nitrogen" and organic matter in Baode Mine is lower than that in JiuLiShan Mine, which is related to the content of the gangue and the mineral structure of the gangue itself. The pH of both gangue leachates was weakly alkaline, which may be due to the buffering effect of ammonia nitrogen on acids and bases. Throughout the experiment, both gangue organic matter had lower humification, less unsaturated aromatic compounds, and the UV254 of their leachates showed a decreasing trend, with little correlation with DOC. The research findings can help to scientifically evaluate the ecological and environmental impacts of coal gangue, and can also provide an important theoretical basis for the resource utilization of coal gangue.